Cutaneous Lymphoma


Primary cutaneous lymphomas are those malignant lymphoproliferative disorders of B or T lymphocytes, whose first manifestation is the presence of human skin lesions without extracutaneous disease occurs at the time of diagnosis, being observed nodal or visceral disease course. The skin is the 2nd location (after the location gastrointestinal) in frequency of primary extranodal lymphomas. Unlike non-Hodgkin lymphomas ganglion that are mostly B-cell lymphomas, 75% of primary lymphomas are T-cell lymphomas, with two thirds of cases mycosis fungoides and Sezary syndrome. The incidence of cutaneous T has progressively increased and is currently of 6.4 cases per million. The incidence increases significantly with age, with an average age of diagnosis 50 years and is 4 times more frequent over 70 years.

Pathogenesis Of Cutaneous Lymphomas

There are several pathogenic mechanisms for the development of cutaneous lymphomas including chromosomal translocations, alterations in tumor suppressor genes (bcl2), immunological and external factors such as viral infections. Skin contains some characteristics suitable for the development of lymphomas, it is estimated that normal skin contains approximately 1 million cells per cubic centimeter T, consequently the skin is an important lymphoid organ and containing eldoble of T cells from peripheral blood. Skin, like the lymph node has several compartments in which are distributed T and B lymphocytes Usually T cells are distributed mostly in the epidermis, papillary dermis, superficial vascular plexus, perianexialmente and the deep portion of subcutaneous fat (in the ganglion are distributed in the paracortex and medulla). B lymphocytes are in the middle and deep dermis, deep vascular plexus and fat tissue (in the ganglion are distributed in the cortex and medulla), this partitioning is accompanied by a cytokine secretion pattern characteristic. This distribution of lymphocyte subpopulations gives a histological pattern for different forms of primary cutaneous lymphoma and cutaneous mycosis fungoides type presented a histological pattern epidermotropo while B and T lymphomas, mycosis fungoides not have a diffuse pattern without epidermotropism or perivascular.

Diagnosis Of Primary Cutaneous Lymphomas

Making the diagnosis of cutaneous lymphoma requires a wide range of clinical and pathological studies to correctly classify the sick. These studies include clinical examination, radiological, histological and molecular studies. Patients with suspected primary cutaneous lymphoma should undergo a thorough clinical examination including thoraco-abdominal radiographic studies (CXR, CT chest and abdomen) and bone marrow examination, all in connection with the diagnosis of suspicion . Histological studies should include study of hematoxylin and eosin, PAS and Giemsa. They also performed immunohistochemical studies with antibodies against antigens characteristic of different cell subpopulations of lymphocytes, macrophages, and dendritic interdigitating cells. Gene rearrangement analysis by Southern blot techniques and PCR (PCR / DGGE) of the genes of the T cell receptor (TCR) and immunoglobulins are useful techniques in the study of cutaneous since they can provide data on the presence of clones of lymphocytes.

Classification Of Cutaneous Lymphomas

There are several ways to classify lymphomas, has recently reached a consensus classification that groups the classification of the WHO and EORTC ( Blood 2005) which replaces the previous, independent of the WHO and EORTC .

Cutaneous T-cell lymphomas

Mycosis Fungoides

It is the most common form of primary cutaneous lymphoma, is a cutaneous T-cell lymphoma, often epidermotropo characterized by a proliferation of T lymphocytes with small or medium-sized cerebriform nucleus. It was first described in 1806 by Alibert receiving its name from the appearance of the lesions fungoides cutaneous tumor. It has an incidence of 0.29 cases / 100,000 population per year, with a peak age between 55 and 60. The clinical manifestations are very varibles from single lesions to erythroderma.

Lymphoma Survival Rate

Lymphoma is a type of cancer that affect the lymphocytes which is part of immune systems. There exist about 35 different subtypes of lymphoma. Due to many types of lymphomas, lymphomas classification becomes very complicated. Lymphatics is composed of vessels which carry lymph fluid which contain the white blood cell. The white blood cells destroy abnormal cells. Lymphoma will result if the white blood cells are impacted and uncontrollably multiply. As cell multiply they form a tumor. The tumor invade the space of surrounding cells and thus overwhelm them. lymphocytes which are abnormal travel to the remote cells. Two types of lymphoma do exist ie Non-Hodgkin and Hodgkin type of lymphoma. The two types of diseases have different survival rates.

H.I.V., genetics, infections, aging and immunodeficiency disease are main diseases which are believed to cause lymphoma. Some of the common symptoms of the diseases include loss of weight, fatigue, sweating during the night, loss of appetite, itching frequently and fever.

Young adults between the age of 16 years and 34 years are the ones who are mostly affected by Hodgkin lymphoma, and the incidence rate is higher in males than in females. There are five subtypes of Hodgkin disease. This type of disease has an occurrence rate of about 7.2% and it is more common in caucasians than in african americans.

For young adults who are below 20 years the disease has a survival rate of 95.5%. In the past 30 years the death rate has decreased by about 3% in men and 3.7% in women. Non-Hodgkin type of lymphoma is more common than Hodgkin with 6.6% occurrence rate. There are about 30 different subtypes of Non-Hodgkin disease and it is likely to occur at old age. The lymphoma survival rate has raised to 84.4% in the last five years. Non-Hodgkin type is ranked position nine among the common death causes in males and sixth in women. By 2010 the number of new cases expected was 66,000 for Non-Hodgkin disease and about 8,500 for Hodgkin disease. By the same year around 20,000 people were expected to have died of NHL and 1,300 due to Hodgkin in the united states of America. These two type of lymphoma demonstrate similar symptoms and they usually have the same physical appearance but can be distinguished on microscopic examinations. According to the research lymphoma is one of the common type of blood cancer in USA.

Patients below the age of 45 years usually survives for a long period. lymphoma is curable if detected at early stages if it is slow lymphoma. Indolent lymphoma may go undetected until advanced stages and the patients can survive for 7- 10 years. Early diagnosis and use drugs can extend this period.

Aggressive type of lymphoma usually need aggressive treatment. It is of the opinion of the doctors that this type of lymphoma is curable if detected on its early stages.

Healthy eating like eating fruits and vegetables, avoiding fatty food, avoid smoking and alcohol, do a lot of exercises, learn manage your stress, sleep for enough number of hours help to reduce lymphoma. Lymphoma is usually incurable except in some cases but chemotherapy and radiotherapy can be used to reduce pain. With these type of treatment the patient can live a healthy life.

Is There An Alternative Lymphoma Treatment?

Lymphoma is a cancer that usually starts in your lymph glands and then spreads to other organs in the body. Often the treatment for Lymphoma is chemotherapy. Is there an alternative lymphoma treatment that will help rid the body of lymphoma? Many people are looking for natural cures that can help with cancer treatments. You should not try any treatments without discussing them with your doctor. There is a good chance he will know of alternatives that will work well with traditional therapies.


Alternative Lymphoma Treatment – Herbs and Supplements

Vitamin D has been found to work well in treating lymphoma. When the body has enough Vitamin D it can help with the treatment of Lymphoma. People who have low Vitamin D levels have shown to be more of a risk to lymphoma than other people. It has been found to very helpful in the treatment of this disease.

Indole 3-carbinol is another supplement that could be very useful in treating lymphoma. It is found in certain vegetables such as cabbage, kale, cauliflower and Brussels sprouts.

Alternative Lymphoma Treatment – Diet

Believe it or not your diet can affect the growth of lymphoma. Lymphoma feeds off of certain nutrients that are taken into the body through food. It will feed off of glucose. By monitoring how much glucose you take into your body you can retard the growth of lymphoma. That means you will need to have a certain diet that is low in carbohydrates, glucose and amino acids. Several doctors now realize that diet can play an important part in treating lymphoma and will be able to help you start a healthy diet.

Alternative Lymphoma Treatment – Naturopathic Medicine

Naturopathic Medicine looks at a person as an individual and uses the resources nature has provided to come up with a plan that works for each individual. Naturopathic medicine helps by enhancing the metabolism of the body, boosting immune systems, increasing energy levels and decreasing the side effects of chemotherapy treatments. This is used along with traditional treatments to help you feel better during your chemo treatment.

Alternative Lymphoma Treatment – Mind and Body

Learning yoga and other forms of meditation will help you to cope with the stresses of Lymphoma. This is not a treatment that focuses on the disease but it will help with the emotional coping abilities. Meditation may also help with the side effects of traditional treatments.

Alternative Treatments and You

As you can see you have alternatives for treatment of lymphoma. You should not use any treatments without discussing them with your doctor first. There is a very real possibility that he will help you with alternative treatments. The goal of the doctor is to help you get better and to cope with this illness. If alternative treatments work, your doctor will likely know about them and will put you on alternative treatments along with traditional treatments like chemo.

It is never too late to try alternative treatments. You could end up feeling better and you could lessen symptoms and maybe even get cured with the use of alternative and traditional treatments.